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AP-1
ββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
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AP-1 ist ein Transkriptionsfaktor. AP-1 ist ein heterodimerer Proteinkomplex aus Proteinen der Familien ATF, JDP, c-Fos und c-Jun und bindet als Dimer an DNA, um die Transkription bestimmter Gene einzuleiten.
Contents
β’ Eigenschaften
β’ Einzelnachweise
ββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
Eigenschaften
Die von AP-1 regulierten Gene umfassen Gene der Zelldifferenzierung, der Zellteilung und der Apoptose.cite-ref-pmid14585541-1-0[1] Die Genexpression des AP-1 selbst wird durch Zytokine, Wachstumsfaktoren, Infektionen und Stressfaktoren induziert.cite-ref-pmid15564374-2-0[2] AP-1 bindet an die DNA ΓΌber basische AminosΓ€uren, wΓ€hrend die Dimerisierung durch einen Leucin-Zipper vermittelt wird.cite-ref-pmid7816143-3-0[3] AP-1 verstΓ€rkt die Genexpression am 12-O-Tetradecanoylphorbol-13-acetate DNA response element (TRE, Sequenz 5'-TGAG/CTCA-3').cite-ref-pmid15564374-2-1[2]
Einzelnachweise